1,2-Dichloroethane is a major commodity chemical that is used, for example, in the manufacture of vinyl chloride. It is a moderately reactive alkylating agent, thus leading to concerns about its environmental fate. Bacteria capable of metabolizing 1,2-dichloroethane have been identified. This metabolism (Janssen et al., 1994) has become a model for bacterial hydrolytic dehalogenation of chlorinated aliphatic compounds (Janssen et al., 1995).
The following is a text-format 1,2-dichloroethane degradation pathway map. Follow the links for more information on compounds or reactions. Organisms which can initiate the pathway are given, but other organisms may also carry out later steps. This map is also available in graphic (9k) format.
1,2-Dichloroethane
Xanthobacter autotrophicus GJ10
Ancylobacter aquaticus AD20, AD25, and AD27
|
|
| haloalkane dehalogenase
|
|
v
2-Chloroethanol
|
|
| pyrrolo-quinoline quinone-containing
| alcohol dehydrogenase
|
v from the
Chloroacetaldehyde <-- 2,4-Dichlorophenoxyacetic Acid
| Pathway
|
| NAD-dependent aldehyde dehydrogenase
|
|
v from the
Chloroacetic acid <-- 1,2,4-Trichlorobenzene
| Pathway
|
| haloacetate dehalogenase or
| 2-haloacid dehalogenase
|
v
Glycolate
|
|
|
|
|
v
Intermediary
Metabolism
(KEGG)
Page Author(s): Renhao Li
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